Double-blind, randomized, placebo-controlled study
method at weeks 0 and 12. All adverse events were recorded.
in the treatment of acne vulgaris
A. Charakida, M. Charakida and A.C. Chu
Department of Dermatology, Hammersmith Hospital, DuCane Road, London W12 0NN, U.K.
Correspondence
A. Charakida.
E-mail: k.charakida@imperial.ac.uk
Accepted for publication
22 April 2007 Key words
acne, ethyl linoleate, randomized controlled trial,
sebum production, treatment, triethyl citrate
Conflicts of interest
None declared.
Summary
Background Acne vulgaris is a major clinical problem; despite a vast array of treatment
modalities available for acne, there is considerable dissatisfaction in acne
treatment among patients and doctors. Rising antibiotic drug resistance consequent
to the widespread use of topical antibiotics is causing concern and effective
nonantibiotic treatments are needed.
Objectives To evaluate the efficacy and tolerability of a novel lotion containing
triethyl citrate and ethyl linoleate in the treatment of mild to moderate acne
vulgaris.
Methods This was a double-blind, placebo-controlled, randomized study comparing
the active lotion containing triethyl citrate and ethyl linoleate with its vehicle as
a placebo control. Patients were assessed by the modified Leeds acne grading system
as well as by counting inflammatory and noninflammatory lesions on the
face at weeks 0, 4, 8 and 12. Sebum production was assessed by the Sebutape
method at weeks 0 and 12. All adverse events were recorded.
Double-blind, randomized, placebo-controlled study
method at weeks 0 and 12. All adverse events were recorded.
in the treatment of acne vulgaris
A. Charakida, M. Charakida and A.C. Chu
Department of Dermatology, Hammersmith Hospital, DuCane Road, London W12 0NN, U.K.
Correspondence
A. Charakida.
E-mail: k.charakida@imperial.ac.uk
Accepted for publication
22 April 2007 Key words
acne, ethyl linoleate, randomized controlled trial,
sebum production, treatment, triethyl citrate
Conflicts of interest
None declared.
Summary
Background Acne vulgaris is a major clinical problem; despite a vast array of treatment
modalities available for acne, there is considerable dissatisfaction in acne
treatment among patients and doctors. Rising antibiotic drug resistance consequent
to the widespread use of topical antibiotics is causing concern and effective
nonantibiotic treatments are needed.
Objectives To evaluate the efficacy and tolerability of a novel lotion containing
triethyl citrate and ethyl linoleate in the treatment of mild to moderate acne
vulgaris.
Methods This was a double-blind, placebo-controlled, randomized study comparing
the active lotion containing triethyl citrate and ethyl linoleate with its vehicle as
a placebo control. Patients were assessed by the modified Leeds acne grading system
as well as by counting inflammatory and noninflammatory lesions on the
face at weeks 0, 4, 8 and 12. Sebum production was assessed by the Sebutape
method at weeks 0 and 12. All adverse events were recorded.